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Raman spectroscopy of advanced glycation end products (AGEs), possible markers for progressive retinal dysfunction
Author(s) -
Pawlak Anna M.,
Beattie J. Renwick,
Glenn Josephine V.,
Stitt Alan W.,
McGarvey John J.
Publication year - 2008
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.2011
Subject(s) - raman spectroscopy , glycation , retinal , macular degeneration , raman microspectroscopy , microscopy , chemistry , pathology , ophthalmology , medicine , biochemistry , optics , physics , receptor
Raman microscopy is used to investigate the spectral features of selected compounds known to be involved in the development of the eye disease age‐related macular degeneration (AMD). Diagnostic features were identified in synthetic samples of these compounds and in a biological matrix. The study demonstrates the potential of Raman microscopy for the development of diagnostic markers of the onset of AMD. Copyright © 2008 John Wiley & Sons, Ltd.