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Characterization of select members of the Taxane family using Raman spectroscopy
Author(s) -
Cipriani Penelope,
BenAmotz Dor
Publication year - 2005
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.1405
Subject(s) - raman spectroscopy , docetaxel , taxane , chemistry , ab initio , analytical chemistry (journal) , computational chemistry , organic chemistry , cancer , optics , medicine , physics , breast cancer
Experimentally derived Raman spectra of three members of the taxane family are presented and discussed. The taxoids investigated were docetaxel (Taxotere ® ), baccatin III and cephalotaxine. These analytes were studied because of their potent antitumor capability or they are potential precursors for the synthesis of highly valuable pharmaceutical drugs. Drop coating deposition Raman (DCDR) spectroscopy is utilized in order to examine the vibrational wavenumbers of the powders and solutions, down to concentrations as low as 1 µ M . Normal Raman modes of two of the three taxanes are confirmed by comparing experimental spectra with related literature and quantum mechanical ab initio calculations. Copyright © 2005 John Wiley & Sons, Ltd.