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Raman spectroscopic study of the effects of opiates on dipalmitoylphosphatidylcholine dispersions
Author(s) -
Yova D.,
Zouboulis I.,
Liarokapis E.,
Loukas S.
Publication year - 1990
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.1250210407
Subject(s) - dipalmitoylphosphatidylcholine , raman spectroscopy , thermotropic crystal , chemistry , analytical chemistry (journal) , phospholipid , chromatography , organic chemistry , liquid crystalline , phase (matter) , membrane , optics , biochemistry , physics , phosphatidylcholine
The effects of the opiates levorphanol and naloxone on the thermotropic properties of dipalmitoylphospalidylcholine (DPPC) multilamellar dispersions were studied using Raman spectroscopy. The spectra of DPPC dispersions were recorded in the CH stretching mode region. By examining the intensity ratios I 2880 / I 2850 and I 2930 / I 2880 as a function of temperature, it was found that opiates lowered the pretransition temperature of DPPC by 2°C and decreased the lateral packing of the acyl chains of the phospholipids.