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Fourier transform infrared and Raman microprobe spectra of some silylated ribonucleosides
Author(s) -
Butler Ian S.,
Xu Zhen H.,
Ogilvie Kelvin K.
Publication year - 1989
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.1250200608
Subject(s) - chemistry , raman spectroscopy , uracil , microprobe , uridine , infrared , fourier transform infrared spectroscopy , chloride , infrared spectroscopy , hydrogen bond , spectral line , analytical chemistry (journal) , molecule , crystallography , organic chemistry , mineralogy , optics , dna , rna , biochemistry , physics , astronomy , gene
The FT‐IR and laser micro‐Raman spectra of ten silylated nucleoside derivatives of uridine and their synthetic precursors, tert ‐butyldimethylsilyl chloride and monomethoxytrityl chloride, were measured at room temperature. Some spectral differences are clearly evident for the 2′‐ and 3′ ‐silylated isomers; such distinctions are difficult to observe by other spectroscopic methods (e.g. 1 H NMR spectroscopy). The differences in the positions of the CO stretching vibrations for the uracil base in uridine and the silylated derivatives are due chiefly to variations in the extent of hydrogen bonding in the solids. In addition, several bands attributable to SiO modes in the silylated compounds have been assigned.