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Inverse Raman spectroscopy of bilirubin and its ditauride
Author(s) -
Hillig Kathy J. Dien,
Morris Michael D.
Publication year - 1984
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.1250150416
Subject(s) - raman spectroscopy , hydrogen bond , chemistry , pyrrole , chloroform , bilirubin , aqueous solution , sulfoxide , photochemistry , dimethyl sulfoxide , molecule , organic chemistry , optics , physics , medicine , gastroenterology
The inverse Raman spectrum of bilirubin and bilirubin ditauride were measured under pre‐resonant conditions. Spectra in chloroform and dimethyl sulfoxide were assigned by comparison with model compounds and on the basis of the known effects of the solvents on the internal hydrogen bonding in bilirubin. The band assignments were used to interpret the spectra of bilirubin ditauride in aqueous solution. Evidence is presented for strong hydrogen bonding to the pyrrole NH bonds and to the lactam rings. It is proposed that hydrogen bonding to water is facilitated by photoactivation and, in turn, stabilizes photohiliruhin.