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Raman spectral studies of bleomycin A 2 and related structural fragments: A probe for bleomycin–DNA interactions
Author(s) -
Freedman Teresa B.,
Santillo Frank S.,
Zimba Carl G.,
Nafie Laurence A.,
Dabrowiak James C.
Publication year - 1983
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.1250140411
Subject(s) - raman spectroscopy , chemistry , bleomycin , crystallography , spectral line , moiety , stereochemistry , molecular physics , analytical chemistry (journal) , optics , physics , organic chemistry , biology , chemotherapy , astronomy , genetics
Raman spectra have been obtained for bleomycin A 2 and selected fragments. Virtually all of the features in the bleomycin Raman spectrum can be attributed to the preresonance enhanced vibrational transitions of the 2,4′‐bithiazole moiety as determined by comparison to the Raman spectra of bithiazole fragments. The Raman spectrum of bleomycin is dominated by a very intense band at 1542 cm −1 that can be approximately assigned as a bithiazole ring stretching mode. This feature may serve as a probe of bithiazole environment in bleomysin ‐DNA interactions.