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Raman and infrared studies on new anticancer inorganic ring systems. 2—Pentaziridinocyclodiphosphathiazene (NPAz 2 ) 2 NSOAz, Az = (NC 2 H 4 )
Author(s) -
Manfait Michel,
Alix Alain J. P.,
Lahana Roger,
Labarre JeanFrançois
Publication year - 1982
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.1250130109
Subject(s) - raman spectroscopy , chemistry , moiety , infrared , ring (chemistry) , aqueous solution , infrared spectroscopy , crystallography , allotropy , stereochemistry , organic chemistry , phase (matter) , physics , optics , phase diagram
A Raman and infrared investigation of SOAz 2, one of the two allotropic varieties of a new anticancer agent, SOAz, has been made in order to have a better understanding of its interactions with DNA. A third allotropic variety, named SOAz 3, was found to be produced when heating SOAz 2. The SOAz 3 → SOAz 2 transformation is also described. SOAz 3 appears to be the conformation of SOAz in aqueous solution and consequently seems to be the moiety which is responsible for its anticancer effectiveness.