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Raman and infrared study on the interactions between phospholipids and proton donors
Author(s) -
Bertoluzza A.,
Bonora S.,
Fini G.,
Morelli M. A.
Publication year - 1981
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.1250110403
Subject(s) - raman spectroscopy , chemistry , hydrogen bond , infrared , proton , infrared spectroscopy , trichloroacetic acid , phospholipid , polarizability , crystallography , photochemistry , molecule , organic chemistry , biochemistry , physics , quantum mechanics , membrane , optics
Raman and infrared spectra of phosphatidylcholine‐acid mixtures (1:1) are reported and discussed in terms of both general structural and specific interactions as a function of the acidic strength of the proton donor. The infrared spectra indicate the formation of a strong, highly polarizable hydrogen bond with monochloro‐, dichloro‐ and trichloroacetic acids. The complete transfer of the proton from the donor to the phospholipid is observed with hydrochloric acid. The Raman data suggest conformational changes in the lateral packing of the acylic chains of the phospholipid. The importance of both these specific interactions, namely hydrogen bonding and structural modifications, in biological systems is discussed and related to biological activity.