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Dissolution of Extemporaneous Paracetamol Capsules
Author(s) -
Mukhtar Sadaf,
Olsen Warren A,
McLachlan Andrew J
Publication year - 2004
Publication title -
journal of pharmacy practice and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.222
H-Index - 22
eISSN - 2055-2335
pISSN - 1445-937X
DOI - 10.1002/jppr2004344276
Subject(s) - dissolution , polyvinyl alcohol , chromatography , dosage form , dissolution testing , medicine , chemistry , organic chemistry , biopharmaceutics classification system
Aim: To investigate the dissolution characteristics of extemporaneously prepared capsules containing hypromellose and paracetamol tablets. Method: Capsules of varying sizes containing paracetamol (powdered tablets) with varying amounts of hypromellose (4–20% w/w) were extemporaneously prepared. Dissolution was investigated using a USP dissolution testing apparatus. Paracetamol dissolution was quantitated using UV absorption spectrophotometry. The impact of hypromellose content, tablet excipients, capsule size, content weight and mixing methods were investigated. Results: Over a 4‐hour period, paracetamol dissolution decreased with increasing hypromellose content. Paracetamol dissolution was 100% from capsules containing 4% hypromellose and 52 ± 3% from capsules containing 20% hypromellose. Reformulated tablets with different formulations resulted in different dissolution rates. The dissolution rate was faster from small capsules and slower from capsules with a lower content weight. The method used to mix the powders also had a significant effect on the dissolution rate. Conclusion: Modified‐release delivery systems can be extemporaneously prepared from reformulated tablets using hypromellose. Hypromellose content, tablet excipients, capsule size, content weight and mixing methods have an impact on the dissolution rate. J Pharm Pract Res 2004; 34: 276–81.