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Stability of Insulin Aspart in Normal Saline Infusion
Author(s) -
Lim Stephen CB,
Roberts Malcolm J,
Paech Michael J,
Peng Li,
Jones Allan
Publication year - 2004
Publication title -
journal of pharmacy practice and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.222
H-Index - 22
eISSN - 2055-2335
pISSN - 1445-937X
DOI - 10.1002/jppr200434111
Subject(s) - medicine , saline , insulin aspart , insulin , sodium , anesthesia , chromatography , hypoglycemia , chemistry , organic chemistry
Aim: To investigate the stability of insulin aspartin sodium chloride 0.9% (normal saline) during storage and continuous IV infusion. Method: Five bags containing insulin 0.1 unit per mL were prepared for each of the four different experimental conditions‐room temperature, 37°C, 2 to 8°C, and within an IV administration set. Insulin was assayed by high pressure liquid chromatography. Results: The insulin concentration fluctuated for 4 hours and then remained within the prescribed range over a 24‐hour period at both room temperature and 37°C. When stored at 2 to 8°C for eight days, the concentration remained stable after one day and was always within the prescribed range. Infusion through an administration set provided a stable concentration after the initial first hour of infusion. Conclusion: Insulin aspart can be produced in batches in normal saline, stored at room temperature or 37°C for 24 hours or in the refrigerator for eight days, and administered without significant change in the prepared concentration.