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Stability and Compatibility of Morphine, Midazolam and Bupivacaine Combinations for Intravenous Infusion
Author(s) -
La Forgia Simon P,
Sharley Nicholas A,
Burgess Naomi G,
Doeck Christopher J
Publication year - 2002
Publication title -
journal of pharmacy practice and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.222
H-Index - 22
eISSN - 2055-2335
pISSN - 1445-937X
DOI - 10.1002/jppr200232165
Subject(s) - midazolam , morphine , medicine , bupivacaine , anesthesia , high performance liquid chromatography , chromatography , chemistry , sedation
Aim: To establish the stability and compatibility of morphine and midazolam, and morphine, midazolam and bupivacaine infusions prepared at the Royal Adelaide Hospital. Method: A validated stability indicating high performance liquid chromatography (HPLC) method was developed to measure the concentrations of each compound in the infusions over a 42‐day study period. Visual inspection and pH measurement were also carried out on each study day. Results: Midazolam concentration decreased to 86.0% of initial concentration in the morphine and midazolam infusion bags and to 86.3% of the initial concentration in the morphine, midazolam and bupivacaine infusion bags by day 42 of the study. The concentration of midazolam was reduced in both combinations to the 90% acceptable level for stability at day 28. There was no significant decrease in morphine or bupivacaine concentration in either solution during the study period. The drug combinations were compatible to visual inspection over the 42‐day study period showing no change in colour and clarity or any precipitation. Conclusion: Based on these results the infusions tested in this study are chemically stable for up to 28 days. Therefore when protected from light and stored at 22 ± 2°C the expiry date for these products can be set at 28 days.