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Syndrome of Inappropriate Antidiuretic Hormone Secretion Secondary to Venlafaxine
Author(s) -
Alderman Christopher P
Publication year - 2002
Publication title -
journal of pharmacy practice and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.222
H-Index - 22
eISSN - 2055-2335
pISSN - 1445-937X
DOI - 10.1002/jppr200232135
Subject(s) - venlafaxine , medicine , antidiuretic , hyponatremia , endocrinology , hormone , antidepressant , hippocampus
Objective: To present a case of syndrome of inappropriate antidiuretic hormone secretion secondary to treatment with venlafaxine. Clinical features: An 83‐year‐old woman developed significant hyponatraemia during treatment with venlafaxine 75 mg daily. Her serum sodium concentration declined to 125 mmol/L at the nadir. Fluid restriction failed to correct her hyponatraemia; however, a trial of demeclocycline 300 mg four times daily increased serum sodium to 138 mmol/L. Venlafaxine and demeclocycline were both subsequently discontinued and her serum sodium remained within the reference range without further intervention. Discussion: The relationship between syndrome of inappropriate antidiuretic hormone secretion and psychotropic therapy is extensively documented but most reports focus on the association between hyponatraemia and treatment with tricyclic antidepressants or selective serotonin reuptake inhibitors. This case provides additional evidence that venlafaxine may cause SIADH.