Open AccessAnaphylactic Shock Following Intravenous Vitamin K 1
Author(s) -
Corallo Carmela E,
Gillett Mark
Publication year - 1997
Publication title -
the australian journal of hospital pharmacy
Language(s) - English
Resource type - Journals
ISSN - 0310-6810
DOI - 10.1002/jppr1997272146
Subject(s) - medicine , anesthesia , anaphylactic shock , anaphylaxis , vitamin , rash , shock (circulatory) , ceftriaxone , bronchospasm , surgery , antibiotics , allergy , microbiology and biotechnology , immunology , biology , asthma
Aim: To describe a case of anaphylactic shock following the intravenous administration of vitamin K 1 Clinical features: A 64‐year‐old male was admitted to intensive care following repair of an aortic abdominal aneurysm. Intravenous amiodarone, ceftriaxone, vancomycin and metronidazole were commenced without incident. During the administration of intravenous vitamin K 1 (phytomenadione, Konakion) the patient developed a rash, hypotension and severe bronchospasm. Outcome: The patient recovered following paralysis, manual ventilation, and standard medication for anaphylaxis. Conclusion: Intravenous administration of vitamin K 1 and other drugs solubilised with polyoxyl 35 castor oil occasionally causes severe anaphylactic shock. A new colloidal formulation may reduce the hazards of intravenous vitamin K 1 administration. Aust J Hosp Pharm 1997; 27: 146–7.