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Pregabalin‐induced parkinsonism 72 hours after iodinated contrast administration
Author(s) -
PradoMel Elena,
GilLópez Marìa,
NavarroCorrales Maria del Carmen
Publication year - 2018
Publication title -
journal of pharmacy practice and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.222
H-Index - 22
eISSN - 2055-2335
pISSN - 1445-937X
DOI - 10.1002/jppr.1363
Subject(s) - pregabalin , medicine , parkinsonism , discontinuation , exacerbation , anesthesia , adverse effect , renal function , surgery , disease
Background Pregabalin is a drug which requires dose adjustment when renal clearance decreases below 60 mL/min. Aim We describe a case in which a 58‐year‐old woman, taking pregabalin for 3 years, developed symptoms of parkinsonism due to worsening of her kidney failure. Clinical details A 58‐year‐old woman developed symptoms of parkinsonism characterised by bradypsychia and drowsiness, inability to ambulate, stiffness in the extremities and loss of facial expression. Four days earlier the patient had undergone an abdominal computed axial tomography scan with iodinated contrast medium and her renal function had failed. Neurological exploration and image testing were performed with inconclusive results. Her treatment was revised and pregabalin was discontinued. Outcomes Parkinsonian symptoms disappeared 10 days after the discontinuation of pregabalin. Conclusions This is the first reported case of pregabalin‐induced parkinsonism associated with acute renal failure or exacerbation of chronic renal failure. The monitoring of renal function in patients taking pregabalin is essential to prevent future similar adverse events .