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Periodontal conditions and incident dementia: A nationwide Swedish cohort study
Author(s) -
Holmer Jacob,
Eriksdotter Maria,
Häbel Henrike,
Hed Myrberg Ida,
Jonsson Anton,
Pussinen Pirkko J.,
GarciaPtacek Sara,
Jansson Leif,
SandborghEnglund Gunilla,
Buhlin Kåre
Publication year - 2022
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1002/jper.21-0518
Subject(s) - dementia , medicine , cohort study , cohort , dentistry , disease
Background Periodontal disease has been proposed as a putative etiological factor for dementia. The aim of this investigation was to compare the incidence of dementia in individuals with or without deep probing pocket depths (DPPD), serving as a proxy for periodontitis. Methods In this cohort study, conducted in Sweden, we identified 7992 individuals with DPPD and 29,182 matched individuals without DPPD (non‐DPPD), using the Swedish Quality Registry for Caries and Periodontal Diseases (SKaPa). The two groups were followed for incident dementia (mean follow‐up time was 7.6 years) based on data from the Swedish Dementia Registry (SveDem). The exposure‐outcome relationship was explored by applying the Royston‐Parmar (RP) flexible parametric survival model. Results The incidence of dementia in the two groups was similar. In the DPPD group 137 (1.7%) developed dementia and 470 (1.6%) in the non‐DPPD group. The incidence rate of dementia was estimated to be 2.3 per 1000 person‐years (95% confidence interval [CI] 1.9 to 2.7) in the DPPD group and 2.1 per 1000 person‐years (95% CI 1.9 to 2.3) in the non‐DPPD group. The RP model disclosed no association between DPPD and dementia incidence after controlling for potential confounders (the exponentiated coefficient was estimated to 1.13 [95% CI = 0.39 to 3.24]). Conclusion In this sample, no association was revealed between deep probing pocket depths and the incidence of dementia.