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Leucine‐rich alpha‐2 glycoprotein (LRG): A novel acute phase protein expressed in Stage 3 Grade C periodontitis before and after periodontal therapy
Author(s) -
Keles Yucel Zeynep Pinar,
Balli Umut
Publication year - 2021
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1002/jper.20-0358
Subject(s) - periodontitis , medicine , chronic periodontitis , proinflammatory cytokine , acute phase protein , tumor necrosis factor alpha , gastroenterology , aggressive periodontitis , alpha (finance) , interleukin , inflammation , immunology , cytokine , surgery , construct validity , patient satisfaction
Background Leucine‐rich alpha‐2 glycoprotein (LRG) is a novel acute phase protein involved in inflammation‐associated diseases and that considered to be induced by multiple proinflammatory cytokines. This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)‐6 and tumor necrosis factor (TNF)‐α in patients with Stage 3 periodontitis before and after non‐surgical periodontal treatment. Methods Twenty‐five Stage 3 periodontitis and twenty‐five periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; periodontitis patients received non‐surgical periodontal treatment, and GCF and serum samples were obtained at baseline and at 6 weeks after treatment. LRG, IL‐6 and TNF‐α were determined by ELISA. Results GCF and serum LRG, IL‐6 and TNF‐α were significantly higher in periodontitis group than healthy controls ( P < .001). A significant decrease in GCF and serum LRG, IL‐6 and TNF‐α was detected after periodontal treatment compared with baseline values of periodontitis patients ( P < .001). Conclusion Our findings revealed that LRG expression was increased in Stage 3 periodontitis both locally and systemically, and non‐surgical periodontal therapy was effective in reducing LRG levels in GCF and serum of these patients.