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C‐reactive protein levels are associated with periodontitis and periodontal inflamed surface area in adults with end‐stage renal disease
Author(s) -
Schöffer Caroline,
Oliveira Leandro Machado,
Santi Samantha Simoni,
Antoniazzi Raquel Pippi,
Zanatta Fabricio Batistin
Publication year - 2021
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1002/jper.20-0200
Subject(s) - medicine , periodontitis , c reactive protein , end stage renal disease , periodontal examination , confounding , gastroenterology , clinical attachment loss , hemodialysis , chronic periodontitis , kidney disease , periodontal disease , inflammation , dentistry
Background Several studies have shown the relationship between periodontal disease and chronic kidney disease, but there is little evidence to assess the impact of the amount of inflamed periodontal tissue on the levels of systemic inflammatory markers. So the aim of this study is determine the association between high‐sensitivity C‐reactive protein (hsCRP) and both periodontitis and periodontal inflamed surface area (PISA) in adults with end‐stage renal disease (ESRD). Methods Cross‐sectional study was conducted with 176 adults with ESRD on regular hemodialysis. The participants were submitted to a full‐mouth periodontal examination to determine the occurrence of periodontitis and PISA. Regression analysis was performed to test the independent association between periodontal conditions and serum hsCRP levels. Results A total of 98.9% of the participants had periodontitis, with stages III and IV found in 26.1% and 52.9%, respectively. Mean hsCRP and PISA was 6.57 (SD: 6.03) mg/L and 217.15 (SD: 271.50), respectively. In the adjusted analysis, mean serum hsCRP levels were significantly higher in patients with stage III and IV generalized periodontitis compared with no/localized/generalized stages I‐II (7.67 mg/L versus 5.72 mg/L, P = 0.028). After adjustments for confounding variables, individuals with PISA >490.56 mm 2 (85th percentile) had a 3.26‐fold greater chance of having hsCRP above 5 mg/L than their counterparts (OR = 3.26; 95% CI: 1.25 to 8.49). Conclusion The inflammatory burden imposed by periodontitis can increase serum hsCRP levels in adults with end‐stage renal disease.