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Effects of different antidepressant classes on dental implant failure: A retrospective clinical study
Author(s) -
Hakam Abeer Essam,
Vila Gabriela,
Duarte Poliana Mendes,
Mbadu Marcia Phemba,
AI Angary Dania Sulaiman,
Shuwaikan Hotoun,
Aukhil Ikramuddin,
Neiva Rodrigo,
da Silva Hélio Doyle Pereira,
Chang Jia
Publication year - 2021
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1002/jper.19-0714
Subject(s) - antidepressant , medicine , implant failure , reuptake inhibitor , implant , odds ratio , retrospective cohort study , confidence interval , serotonin reuptake inhibitor , surgery , hippocampus
Background Previous studies have suggested an association between taking antidepressants and dental implant failure. This study aimed to investigate the association of different antidepressant classes with dental implant failure. Methods This retrospective study included patients that received dental implants at the University of Florida from 2011 to 2016. The variables of implant failure, antidepressant use and classes (selective serotonin reuptake inhibitors [SSRI], serotonin‐norepinephrine reuptake inhibitors [SNRI], tricyclic antidepressants [TCA], atypical antidepressants [AA], and monoamine oxidase inhibitors [MAOI]), age, sex, smoking, mild systemic diseases, and implant location were obtained from patients’ records. Odds ratio (OR) and confidence interval (CI) of implant failure in patients taking different antidepressant classes, in relationship to non‐antidepressant users, were estimated, and the influence of multiple variables on implant failure were investigated. Results A total of 771 patients and 1,820 implants were evaluated. The statistically significant predictors for implant failure included smoking (OR = 5.221), use of antidepressants (OR = 4.285), posterior maxilla location (OR = 2.911), mild systemic disease (OR = 2.648), and age (OR = 1.037) ( P <0.05). The frequency of implant failure was 33.3% in TCA users, 31.3% in SNRI users, 6.3% in SSRI users, 5.2% in Atypical antidepressant users, and 3.9% in non‐users. Significant associations were observed between the use of SNRI (OR: 11.07; 95% CI: 3.265 to 33.82) and TCA (OR: 12.16; 95% CI: 1.503 to 71.58) and implant failure ( P <0.05). Conclusions Users of antidepressants were at higher risk of implant failure than non‐users. Patients taking SNRI and TCA were at the highest risk of implant loss, when compared with non‐users. Conclusions about TCA, however, are based on a limited number of cases.