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Living cell‐based regenerative medicine technologies for periodontal soft tissue augmentation
Author(s) -
McGuire Michael K.,
Tavelli Lorenzo,
Feinberg Stephen E.,
Rasperini Giulio,
Zucchelli Giovanni,
Wang HomLay,
Giannobile William V.
Publication year - 2020
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1002/jper.19-0353
Subject(s) - regenerative medicine , soft tissue , regeneration (biology) , dentistry , medicine , tissue engineering , scaffold , wound healing , hard tissue , tissue repair , biomedical engineering , surgery , cell , biology , genetics , microbiology and biotechnology
The cultivation of human living cells into scaffolding matrices has progressively gained popularity in the field of periodontal wound healing and regeneration. Living cellular constructs based on fibroblasts, keratinocytes alone or in combination have been developed and used as alternatives to autogenous soft tissue grafts in keratinized tissue augmentation and in root coverage procedures. Their promising advantages include reduced patient morbidity, unlimited graft availability, and comparable esthetics. This manuscript reviews soft tissue augmentation and root coverage procedures using bioengineered living cellular therapy and highlights their expected clinical, esthetic, and patient‐related outcomes.