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Biologics‐based regenerative technologies for periodontal soft tissue engineering
Author(s) -
Tavelli Lorenzo,
McGuire Michael K.,
Zucchelli Giovanni,
Rasperini Giulio,
Feinberg Stephen E.,
Wang HomLay,
Giannobile William V.
Publication year - 2020
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1002/jper.19-0352
Subject(s) - enamel matrix derivative , medicine , dentistry , regeneration (biology) , growth factor , soft tissue , tooth root , regenerative medicine , matrix (chemical analysis) , pathology , biology , stem cell , materials science , microbiology and biotechnology , receptor , composite material
This manuscript provides a state‐of‐the‐art review on the efficacy of biologics in root coverage procedures, including enamel matrix derivative, platelet‐derived growth factor, platelet concentrates, and fibroblast‐growth factor‐2. The mechanism of action and the rationale for using biologics in periodontal plastic surgery, as well as their anticipated benefits when compared with conventional approaches are discussed. Although the clinical significance is still under investigation, preclinical data and histologic evidence demonstrate that biologic‐based techniques are able to promote periodontal regeneration coupled with the provision of tooth root coverage.