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Anemia of inflammation associated with periodontitis: Analysis of two clinical studies
Author(s) -
Nibali Luigi,
Darbar Ulpee,
Rakmanee Thanasak,
Donos Nikos
Publication year - 2019
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1002/jper.19-0124
Subject(s) - periodontitis , leukocytosis , medicine , gastroenterology , anemia , hemoglobin , aggressive periodontitis , mean corpuscular hemoglobin , mean corpuscular volume , chronic periodontitis , clinical attachment loss , immunology
Background While leukocytosis is a common feature of severe periodontitis, a smaller amount of evidence has been produced on erythrocytes counts in periodontitis, suggesting a possible tendency to anemia. The aim of this study was to investigate the associations between periodontitis and circulating leukocytes, erythrocytes, and platelets. Methods The study included 471 patients with periodontitis (including aggressive periodontitis [AgP], and chronic periodontitis [CP]) and periodontal health. A separate sample of 333 patients from a previous study (127 AgP and 206 periodontally healthy) was used as replication. Periodontal clinical data were collected and a blood sample was obtained from each participant for hematological analysis of leukocytes, erythrocytes and platelets. Results Adjusted linear regression analyses revealed associations between periodontitis and total leukocytes counts ( p < 0.001), neutrophil counts ( P <0.001) and hematocrit (HCT) levels ( P = 0.045). Sub‐analysis revealed no statistically significant differences between AgP and CP. Disease severity was correlated with total leukocyte and neutrophil counts and HCT ( P <0.001, P <0.001 and P = 0.004, respectively). In the replication sample, adjusted linear regression analysis revealed associations between periodontitis and decreased hemoglobin (HB) ( P = 0.009), mean corpuscular hemoglobin (MCH) ( P = 0.023), and MCH concentration ( P <0.001). A subset of patients included in these studies (14% to 15.7% of periodontitis versus 8.4% to 10.2% of healthy, respectively, in the two cohorts) were anemic based on the World Health Organization criteria. Conclusion This paper, reporting results of periodontal examination and blood sampling in over 800 patients, suggest that not just leukocytosis but also tendency to “anemia of inflammation” are typical features of periodontitis.