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Periodontitis is associated with systemic inflammation and vascular endothelial dysfunction in patients with lacunar infarct
Author(s) -
Leira Yago,
RodríguezYáñez Manuel,
Arias Susana,
LópezDequidt Iria,
Campos Francisco,
Sobrino Tomás,
D'Aiuto Francesco,
Castillo José,
Blanco Juan
Publication year - 2019
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1002/jper.18-0560
Subject(s) - medicine , periodontitis , inflammation , systemic inflammation , endothelial dysfunction , gastroenterology , ptx3 , tumor necrosis factor alpha , serum amyloid p component , interleukin 6 , interleukin , c reactive protein , cytokine
Abstract Background Periodontitis has been associated with lacunar infarct (LI), a type of cerebral small vessel disease. The objective of this study was to ascertain whether periodontitis is associated with increased circulating levels of systemic inflammation and endothelial dysfunction biomarkers in patients with LI. Methods One hundred twenty patients with LI and 120 healthy controls underwent a full‐mouth periodontal examination. The periodontal inflamed surface area (PISA) was calculated for each participant. Demographic, medical, and neurological information were recorded from all of them. In addition, blood samples were collected in order to investigate differences in terms of interleukin (IL)‐6, IL‐10, pentraxin (PTX) 3, soluble fragment of tumor necrosis factor‐like weak inducer of apoptosis (sTWEAK) and amyloid‐beta (Aβ) peptides (i.e., Aβ 1‐40 , and Aβ 1‐42 ) measured in serum. Results Periodontitis was independently associated with increased levels of IL‐6 (R 2 = 0.656, P < 0.001), PTX3 (R 2 = 0.115, P < 0.001), sTWEAK (R 2 = 0.527, P < 0.001), and Aβ 1‐40 (R 2 = 0.467, P < 0.001) in patients with LI. Within patients with poor outcome, PISA positively correlated with IL‐6 (r = 0.738, P < 0.001), PTX3 (r = 0.468, P = 0.008), sTWEAK (r = 0.771, P < 0.001), and Aβ 1‐40 (r = 0.745, P < 0.001). Conclusions Our data suggest a link between periodontitis, systemic inflammatory response, and disruption of the vascular endothelial function in patients with LI. Experimental studies are needed to elucidate possible pathways through which periodontitis could lead to this systemic inflammatory state with impairment of the endothelial function in LI. Further longitudinal studies with large samples are warranted to confirm our findings.