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Comparing the effect of strontium‐functionalized and fluoride‐modified surfaces on early osseointegration
Author(s) -
Offermanns Vincent,
Steinmassl Otto,
Andersen Ole Z.,
Jeppesen Christian S.,
Sørensen Søren,
Talasz Heribert,
Lindner Herbert H.,
Foss Morten,
Kloss Frank
Publication year - 2018
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1002/jper.17-0680
Subject(s) - osseointegration , strontium , titanium , dentistry , fluoride , nuclear chemistry , surface modification , chemistry , materials science , biomedical engineering , implant , medicine , metallurgy , surgery , inorganic chemistry , organic chemistry
Background Studies have shown that medical devices comprising strontium contribute to bone healing and osseointegration. The aim of this study was to evaluate the in vivo performance of surface‐functionalized implants (Ti‐Sr‐O) showing predictable release characteristics of strontium and compare it to performance a commercially available fluoride‐modified surface. Methods Ti‐Sr‐O functionalized, fluoride‐modified, Grade 4 titanium implants were inserted in the femoral condyle of adult male New Zealand white rabbits. Atomic absorption spectrometry (AAS) was utilized to monitor strontium blood serum levels. Two weeks after insertion, histomorphometric evaluation was performed with respect to bone‐to‐implant contact (BIC%) and bone formation (BF%) using defined regions of interest. Results Mean values for BIC% showed a comparable degree of osseointegration for Ti‐Sr‐O and the fluoride‐modified surface, while BF% revealed a significant difference in increased BF with Ti‐Sr‐O. AAS measurements did not indicate any influence of the Ti‐Sr‐O modified implants on the strontium blood serum concentrations. Conclusions Within the limitations of this study, it was shown that the Ti‐Sr‐O coating, with sustained release characteristics of strontium, enhanced bone apposition and, thus, could find practical applications, e.g., within the field of medical implantology.