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High serum procalcitonin levels in patients with periodontitis and chronic migraine
Author(s) -
Leira Yago,
Ameijeira Pablo,
Domínguez Clara,
Leira Rogelio,
Blanco Juan
Publication year - 2018
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1002/jper.17-0603
Subject(s) - procalcitonin , chronic periodontitis , medicine , gastroenterology , migraine , periodontitis , c reactive protein , chronic migraine , inflammation , sepsis
Background To evaluate the contribution of chronic periodontitis (CP) to serum procalcitonin (proCT) levels in chronic migraine (CM) patients in a cross‐sectional study. Methods We included 138 subjects divided into 4 groups based on clinical features of CM and periodontal parameters: systemically and periodontally healthy individuals ( n = 37), systemically healthy and CP patients ( n = 19), CM and periodontally healthy patients ( n = 34), and CM+CP patients ( n = 48). Demographic, neurological, clinical data as well as full‐mouth periodontal records were obtained. ProCT and high sensitive C‐reactive protein (hs‐CRP) serum levels were determined from blood samples taken during migraine interictal period. Results Patients from the CP+CM group (0.056±0.006 ng/mL) had significantly higher serum proCT levels in comparison with the systemically and periodontally healthy group (0.029±0.019 ng/mL), CM group (0.041±0.002 ng/mL), or CP group (0.034±0.014 ng/mL) ( p < 0.001). There were no significant differences in hs‐CRP between groups ( p = 0.081). Multiple linear regression analysis showed that CP was associated with increased proCT levels in CM patients (R 2 = 0.293, p < 0.001). Conclusions CP independently contributes to elevated serum proCT levels in CM patients. These findings suggest that CP could play a role in migraine chronification.