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The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in Japanese adults: A pilot case‐control study
Author(s) -
Kobayashi Tetsuo,
Kido Junichi,
Ishihara Yuichi,
Omori Kazuhiro,
Ito Satoshi,
Matsuura Takato,
Bando Takashi,
Wada Jun,
Murasawa Akira,
Nakazono Kiyoshi,
Mitani Akio,
Takashiba Shogo,
Nagata Toshihiko,
Yoshie Hiromasa
Publication year - 2018
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1002/jper.17-0412
Subject(s) - rheumatoid arthritis , medicine , single nucleotide polymorphism , chronic periodontitis , comorbidity , periodontitis , allele , cohort , case control study , logistic regression , genetic predisposition , arthritis , genotype , disease , genetics , gene , biology
Background A number of studies have suggested a bidirectional relationship of periodontitis with rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM). However, the genetic factors that underlie these relationships have not been elucidated. Methods We conducted a multicenter case‐control study that included 185 patients with RA and chronic periodontitis (CP), 149 patients with T2DM and CP, 251 patients with CP, and 130 systemically and periodontally healthy controls from a cohort of Japanese adults to assess the shared genetic risk factors for RA and CP as well as for T2DM and CP. A total of 17 candidate single nucleotide polymorphisms (SNPs) associated with RA, T2DM, and CP were genotyped. Results Multiple logistic regression analyses revealed that the KCNQ1 rs2237892 was significantly associated with comorbidity of RA and CP ( P = 0.005) after adjustment for age, sex, and smoking status. The carriers of the T allele among patients with RA and CP showed significantly higher disease activity scores including 28 joints using C‐reactive protein values than the non‐carriers ( P = 0.02), although the age, female percentage, and smoking status were comparable. Other SNPs were not associated with comorbidity of RA and CP, T2DM and CP, or susceptibility to CP. Conclusion The results of the present pilot study suggest for the first time that the KCNQ1 rs2237892 may constitute a shared genetic risk factor for RA and CP, but not for T2DM and CP in Japanese adults.