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High Parenteral Support Volume Is Associated With Reduced Quality of Life Determined by the Short‐Bowel Syndrome Quality of Life Scale in Nonmalignant Intestinal Failure Patients
Author(s) -
Nordsten Cecilie Bagi,
Molsted Stig,
Bangsgaard Louise,
Fuglsang Kristian A.,
Brandt Christopher F.,
Niemann Mads J.,
Jeppesen Palle B.
Publication year - 2021
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1002/jpen.1958
Subject(s) - medicine , short bowel syndrome , jejunostomy , quality of life (healthcare) , ileostomy , parenteral nutrition , stoma (medicine) , gastroenterology , surgery , nursing
Background Aim was to investigate the association between quality of life (QoL), bowel anatomy, and the need for home parenteral support (HPS) volume in patients with nonmalignant short‐bowel syndrome (SBS) and intestinal failure (IF). Methods The SBS‐QoL scale was used in a cross‐sectional study of 95 nonmalignant SBS‐IF patients. Sum QoL scores (0: best, 170: worst) were calculated. Patients were defined as having a small bowel (≤200 cm), and patients with jejunostomy or ileostomy were subclassified based on functional small‐bowel length (cm) into 4 anatomy subgroups: 1a–1d (0–49, 50–99, 100–149, 150–200 cm, respectively). Multiple linear regression analyses explored associations between QoL, patient groups, and HPS volume, adjusting for age, sex, body mass index, and education. Results Complete data were obtained from 60 patients. HPS volume was associated with a worse SBS‐QoL score (L/d, β = 7.91; SE = 3.90; P = .048), but male sex associated with improvement (β = −26.28; SE = 11.06; P = .021). No differences in sum QoL were seen between the benign SBS‐IF subgroups 1a–d ( P = .210). Multivariate regression analyses showed that patients with a small‐bowel stoma, a small‐bowel length <50 cm was associated with a significantly worse/higher SBS‐QoL score compared with a length >50 cm. Conclusion In patients with benign SBS‐IF, high HPS volume was associated with poor QoL. Also, jejunostomy or ileostomy with small‐bowel length <50 cm was associated with impaired QoL. These findings support rehabilitation strategies that reduce fecal losses and decrease HPS needs.