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Bone Mineral Composition Among Long‐Term Parenteral Nutrition Patients: Postmortem Assessment of Calcium, Phosphorus, Magnesium, and Select Trace Elements
Author(s) -
Galusha Aubrey L.,
Howard Lyn J.,
Kruger Pamela C.,
Marks Tia,
Parsons Patrick J.
Publication year - 2021
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1002/jpen.1818
Subject(s) - calcium , strontium , phosphorus , barium , zinc , chemistry , magnesium , cadmium , bone mineral , inductively coupled plasma mass spectrometry , manganese , parenteral nutrition , composition (language) , medicine , radiochemistry , nuclear chemistry , mass spectrometry , osteoporosis , inorganic chemistry , chromatography , linguistics , philosophy , organic chemistry
Background Patients receiving long‐term parenteral nutrition (PN) treatment are at risk of developing metabolic bone diseases (MBDs). The bone compartment serves as a repository for a range of metal(loid)s that are administered intravenously to patients via PN solutions. Thus, the mineral composition of patient bones may be linked to the development of MBDs in this group. Methods We measured 12 elements in bone samples obtained post mortem from 7 long‐term (2–21 years) PN patients and 18 control bones obtained from hip/knee replacement surgery. The samples were cleaned, digested, and subsequently analyzed using a method based on inductively coupled plasma tandem mass spectrometry. Results Compared with the control group, bones obtained from PN patients were significantly ( P < 0.05) depleted in calcium (Ca), phosphorus (P), magnesium (Mg), chromium, and strontium and enriched in manganese (Mn), zinc, barium, cadmium (Cd), and uranium (U). No differences were observed for cobalt or lead. Conclusions Depletion of major components of bone mineral (Ca, P, and Mg) and enrichment in known toxicants (Cd, Mn, U) are concerns for PN patients.