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Osteoporosis and Hepatic Steatosis: 2 Closely Related Complications in Short‐Bowel Syndrome
Author(s) -
ParreiraseSilva Luciana T.,
Araújo Iana M.,
Elias Jorge,
NogueiraBarbosa Marcello H.,
Suen Vivian M. M.,
Marchini Julio S.,
Salmon Carlos E.G.,
Paula Francisco José Albuquerque
Publication year - 2020
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1002/jpen.1802
Subject(s) - medicine , adipose tissue , bone mineral , osteoporosis , adipokine , adiponectin , endocrinology , leptin , steatosis , bone density , short bowel syndrome , prospective cohort study , obesity , insulin resistance , parenteral nutrition
Background Osteoporosis has scarcely been prospectively investigated in short‐bowel syndrome (SBS). This prospective study was designed to evaluate incretins, adipokines, bone mass, and lipid deposits from marrow adipose tissue (MAT), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and liver (IHLs). Methods The study comprised 2 groups matched by gender, height, and age: the control group (CG) (9 males, 9 females) and the SBS group (SBSG) (6 males, 5 females). The SBSG was evaluated twice in an interval of 1 year (SBSG 0 and SBSG 1 ). The biochemical evaluation included incretins, leptin, and adiponectin. Dual‐energy x‐ray absorptiometry and magnetic resonance were, respectively, used to measure BMD and lipid deposits. Results Bone mineral density (BMD) was lower in the SBSG than in the CG, but there was no difference between SBSG 0 and SBSG 1 . There was no difference in MAT, SAT, and VAT, but IHL was lower in CG than in SBSG 0 and SBSG 1 . A negative correlation between MAT and third lumbar vertebrae BMD was found in the CG but not in SBSG 0 or SBSG 1 . There was a negative association between IHL and bone mass considering all participants (CG and SBSG 0 ) ( R 2 = 0.38; P < .05). Conclusion Appropriate nutrition assistance recovers body composition, reverts the relationship of bone mass and MAT, and mitigates bone loss in SBS. In spite of this, osteoporosis seems to be an early and persistent complication in SBS. Curiously, SBS seems to be a highly vulnerable condition for the development of hepatic steatosis and shows an association between bone mass and IHL.