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Epidemiology and Risk Factors for Outpatient‐Acquired Catheter‐Related Bloodstream Infections in Children Receiving Home Parenteral Nutrition
Author(s) -
Wozniak Laura J.,
Bechtold Hannah M.,
Reyen Laurie E.,
Chan Alvin P.,
Marcus Elizabeth A.,
Vargas Jorge H.
Publication year - 2018
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1002/jpen.1037
Subject(s) - medicine , parenteral nutrition , epidemiology , catheter , pediatrics , incidence (geometry) , risk factor , chills , intensive care medicine , surgery , physics , optics
Background Few studies have examined the epidemiology and risk factors for the development of outpatient‐acquired catheter‐related bloodstream infections (CRBSIs) in children receiving home parenteral nutrition. This study aimed to (1) characterize the incidence, clinical presentation, and epidemiology of CRBSIs and (2) identify risk factors for CRBSIs in children receiving home parenteral nutrition. Methods A longitudinal database approved by our Institutional Review Board was created to prospectively track CRBSIs in the UCLA pediatric population from January to December 2012. Eligible patients included those < 18 years old receiving home parenteral nutrition. Results Thirty of 60 patients (50%) were diagnosed with 66 CRBSIs, for an overall CRBSI rate of 3.6 per 1000 catheter days. Of the CRBSIs, 73% were due to single microorganisms and 27% were polymicrobial. There was a significant difference in median (range) time for blood cultures to turn positive depending on type of CRBSIs (p = 0.03), with polymicrobial infections detected at 13.4 (8.7–24.3) hours, gram‐negative infections at 16.5 (9–30.8) hours, and gram‐positive infections at 18.9 (8.4–37.1) hours. The most common presenting symptom was fever (82%), followed by gastrointestinal symptoms (42%) and chills (29%). The only significant multivariate risk factor for CRBSIs was presence of a feeding tube (2.3‐fold increase in CRBSI risk, p = 0.04). Discussion Outpatient‐acquired CRBSIs are common in children receiving home parenteral nutrition. CRBSIs typically present with fever, but are also associated with gastrointestinal and/or respiratory symptoms. The presence of feeding tubes may predispose children on home parenteral nutrition to developing CRBSIs.