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A PROSPECTIVE STUDY: INFLAMMATION, INFECTION AND COMORBIDITY IN PATIENTS ON LONG‐TERM DIALYSIS
Author(s) -
Akbaş Türkay,
Mülazımoğlu Lütfiye,
Aksu Burak,
Akoğlu Emel
Publication year - 2014
Publication title -
journal of renal care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.381
H-Index - 27
eISSN - 1755-6686
pISSN - 1755-6678
DOI - 10.1002/jorc.12042
Subject(s) - medicine , diabetes mellitus , comorbidity , fibrinogen , proportional hazards model , gastroenterology , univariate analysis , dialysis , multivariate analysis , endocrinology
SUMMARY Background The goal of this study was to identify inflammatory and infectious markers and their roles in mortality. Methods We enrolled 111 patients on haemodialysis (HD) and collected data at three time points (baseline, 33 and 76 months). Results Rates of Chlamydophila pneumoniae IgG, CRP ≥3 mg/l, ESR >50 mm/hour and fibrinogen >4 g/l were, respectively, 63.1%, 60.4%, 48.6% and 42.3%. Mortality was 21.6% and 43.2% at 33 and 76 months where 58.3% of all deaths were cardiocerebrovascular (CCV) related. Non‐survivors were older than survivors. Univariate analysis showed diabetes mellitus (DM) and cerebrovascular accident (CVA) as important for the 33‐month all‐cause mortality, and CRP log , fibrinogen, ESR >50 mm/hour, cardiovascular disease (CVD) and DM for the 76‐month all‐cause mortality. CVA was meaningful for the 33‐month CCV mortality, and CVD, DM and ESR >50 mm/hour for the 76‐month CCV mortality. Kaplan–Meier revealed poorer survival for patients with ESR >50 mm/hour at 76 months. Cox regression showed CVD, CVA and age as mortality predictors. Conclusion Age, CVD and CVA are predictors for mortality in patients on HD patients, but the presence of C. pneumoniae IgG and inflammation are not.