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Nanotechnology and Osteoarthritis. Part 2: Opportunities for advanced devices and therapeutics
Author(s) -
Lawson Taylor B.,
Mäkelä Janne T. A.,
Klein Travis,
Snyder Brian D.,
Grinstaff Mark W.
Publication year - 2021
Publication title -
journal of orthopaedic research®
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.24842
Subject(s) - nanomedicine , osteoarthritis , nanotechnology , medicine , disease , regeneration (biology) , articular cartilage , intensive care medicine , nanoparticle , materials science , pathology , biology , alternative medicine , microbiology and biotechnology
Osteoarthritis (OA) is a multifactorial disease of the entire joint which afflicts 140 million individuals worldwide regardless of economic or social status. Current clinical treatments for OA primarily center on reducing pain and increasing mobility, and there are limited therapeutic interventions to restore degraded cartilage or slow disease pathogenesis. This second installment of a two‐part review on nanotechnology and OA focuses on novel treatment strategies. Specifically, Part 2 first discusses current surgical and nonsurgical treatments for OA and then summarizes recent advancements in nanotechnology‐based treatments, while Part 1 (10.1002/jor.24817) described advances in imaging and diagnostics. We review nano delivery systems for small molecule drugs, nucleic acids, and proteins followed by nano‐based scaffolds for neocartilage formation and osteochondral regeneration, and lastly nanoparticle lubricants. We conclude by identifying opportunities for nanomedicine advances, and prospects for OA treatments.