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Biological and structural effects after intraosseous infiltrations of age‐dependent platelet‐rich plasma: An in vivo study
Author(s) -
Delgado Diego,
Garate Ane,
Sánchez Pello,
Bilbao Ane Miren,
García del Caño Gontzal,
Salles Joan,
Sánchez Mikel
Publication year - 2020
Publication title -
journal of orthopaedic research®
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.24646
Subject(s) - platelet rich plasma , in vivo , medicine , bone marrow , infiltration (hvac) , pathology , platelet , trabecular bone , biology , osteoporosis , physics , microbiology and biotechnology , thermodynamics
Platelet‐rich plasma (PRP) is an increasingly widespread treatment for joint pathologies. Its characteristics and administration route are variables that may influence the clinical outcome. The aim of this in vivo study was to analyze in aged rats the biological and structure effects of intraosseous infiltrations of two different types of PRP obtained from young and old donors. During 6 months intraosseous infiltrations were performed and 4 days after the last infiltration, animals were sacrificed, and bones were extracted for micro‐computed tomography (micro‐CT) and histological analysis. Molecular composition of the PRP of aged donors presented higher levels of proinflammatory molecules. The histological studies showed a greater cellularity of bone marrow in groups treated with PRP. Concerning micro‐CT analysis, young PRP showed a better femoral bone structure according to values of percentage of trabecular bone, trabecular space, trabecular density, and subchondral bone plate volume. In summary, this study has demonstrated that intraosseous infiltrations of PRP from young donors prevent from age‐related bone degeneration. This treatment could stimulate the biological processes that maintain homeostasis and bone structure and avoid osteoarticular pathologies.