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Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease
Author(s) -
Kaji Deepak A.,
Tan Zhijia,
Johnson Gemma L.,
Huang Wesley,
Vasquez Kaetlin,
Lehoczky Jessica A.,
Levi Benjamin,
Cheah Kathryn S. E.,
Huang Alice H.
Publication year - 2020
Publication title -
journal of orthopaedic research®
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.24523
Subject(s) - regeneration (biology) , underpinning , mesenchymal stem cell , plasticity , stem cell biology , disease , neuroscience , engineering ethics , medicine , biology , pathology , microbiology and biotechnology , engineering , embryo , civil engineering , physics , reproductive technology , embryogenesis , thermodynamics
In this review, we highlight themes from a recent workshop focused on “Plasticity of Cell Fate in Musculoskeletal Tissues” held at the Orthopaedic Research Society's 2019 annual meeting. Experts in the field provided examples of mesenchymal cell plasticity during normal musculoskeletal development, regeneration, and disease. A thorough understanding of the biology underpinning mesenchymal cell plasticity may offer a roadmap for promoting regeneration while attenuating pathologic differentiation. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:708‐718, 2020