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Biomechanics, obesity, and osteoarthritis. The role of adipokines: When the levee breaks
Author(s) -
Francisco Vera,
Pérez Tamara,
Pino Jesús,
López Verónica,
Franco Eloy,
Alonso Ana,
GonzalezGay Miguel Angel,
Mera Antonio,
Lago Francisca,
Gómez Rodolfo,
Gualillo Oreste
Publication year - 2018
Publication title -
journal of orthopaedic research®
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.23788
Subject(s) - osteoarthritis , adipokine , medicine , disease , obesity , adipose tissue , cartilage , pathogenesis , bioinformatics , pathology , leptin , anatomy , biology , alternative medicine
Osteoarthritis is a high‐incidence painful and debilitating disease characterized by progressive degeneration of articular joints, which indicates a breakdown in joint homeostasis favoring catabolic processes. Biomechanical loading, associated with inflammatory and metabolic imbalances of joint, strongly contributes to the initiation and progression of the disease. Obesity is a primary risk factor for disease onset, and mechanical factors increased the risk for disease progression. Moreover, inflammatory mediators, in particular, adipose tissue‐derived cytokines (better known as adipokines) play a critical role linking obesity and osteoarthritis. The present article summarizes the knowledge about the role of adipokines in cartilage and bone function, highlighting their contribution to the imbalance of joint homeostasis and, consequently, pathogenesis of osteoarthritis. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res36:594–604, 2018.