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Physical activity levels and quality of life relate to collagen turnover and inflammation changes after running
Author(s) -
Cattano Nicole M.,
Driban Jeffrey B.,
Barbe Mary F.,
Tierney Ryan,
Amin Mamta,
Sitler Michael R.
Publication year - 2017
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.23250
Subject(s) - medicine , anterior cruciate ligament , biomarker , osteoarthritis , inflammation , meniscus , prospective cohort study , cohort , treadmill , physical therapy , quality of life (healthcare) , surgery , pathology , biochemistry , chemistry , physics , alternative medicine , nursing , incidence (geometry) , optics
The purpose of this study was to determine whether an association existed between self‐reported symptom and function scores and tissue turnover or inflammatory biomarker changes after a running bout among individuals with and without an acute knee‐injury history. A pre‐test/post‐test prospective cohort study design (Level II) of 22 participants was conducted. Eleven physically active individuals with a history of anterior cruciate ligament surgery and/or meniscus surgery within 4 years of study participation were matched to 11 healthy control participants. All participants completed self‐reported outcome measures (Knee Osteoarthritis Outcomes Score and Tegner activity level) assessing knee symptoms and functional levels prior to the run. Blood samples were taken both pre‐ and post‐30‐minute run at a prescribed pace on a treadmill to determine serum biomarker concentration changes. Tegner activity levels were inversely related to type II collagen/type II collagen synthesis marker ratio biomarker changes after the run ( r = −0.45, p = 0.01). Quality‐of‐life scores pre‐exercise were inversely related to interleukin‐1β changes after the run ( r = −0.50, p = 0.02). No other correlation coefficients were statistically significant ( r = −0.39 to 0.36). Ultimately, individuals with lower activity and quality‐of‐life scores experienced greater increases in collagen turnover and inflammation after a running bout, respectively. A gradual increase in activity (e.g., frequency, duration, intensity) may be warranted in this group prior to returning to activities that involve running. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:612–617, 2017.