Premium
T2* mapping of ovine intervertebral discs: Normative data for cervical and lumbar spine
Author(s) -
Kolf AnnaKatharina,
Hesper Tobias,
Schleich Christoph,
Hosalkar Harish S.,
Jankowiak Silvia,
Cacchi Claudio,
Antoch Gerald,
Zilkens Christoph,
Krauspe Rüdiger,
Bittersohl Bernd
Publication year - 2016
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.23071
Subject(s) - medicine , lumbar , sagittal plane , anatomy , intervertebral disc , annulus (botany) , nucleus , biology , botany , psychiatry
ABSTRACT To obtain T2* values in histologically evaluated healthy ovine intervertebral discs of the cervical and lumbar spine. Intervertebral discs of nine sheep and nine lambs underwent histological assessment with the modified Boos score for grading of disc degeneration. Discs with a score <10 points (maximum = 40 points) underwent T2* mapping ( n = 64). Mid‐sagittal T2* values were obtained in five regions: Anterior annulus fibrosus, anterior nucleus pulposus, central nucleus pulposus, posterior nucleus pulposus, and posterior annulus fibrosus. We noted a zonal T2* distribution with high values in the central nucleus and low T2* values in the anterior and posterior annulus fibrosus. The T2* values were higher in lamb than in sheep IVDs for both cervical and lumbar spine ( p < 0.001). The T2* values were also higher in the cervical than in the lumbar spine ( p = 0.029 for sheep and p < 0.001 for lamb IVDs). The T2* values obtained in these ovine intervertebral discs can serve as baseline values for future T2* measurements both in health and disease. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:717–724, 2016.