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Unilateral versus bilateral percutaneous kyphoplasty for osteoporotic vertebral compression fractures: A systematic review and meta‐analysis of RCTs
Author(s) -
Feng Hui,
Huang Peng,
Zhang Xuesong,
Zheng Guoquan,
Wang Yan
Publication year - 2015
Publication title -
journal of orthopaedic research®
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.22957
Subject(s) - medicine , meta analysis , visual analogue scale , randomized controlled trial , percutaneous , surgery , radiological weapon , cochrane library , compression (physics) , quality of life (healthcare) , materials science , nursing , composite material
The purpose of this research was to compare the efficacy and safety of unilateral versus bilateral PKP for osteoporotic vertebral compression fractures (OVCFs). Six databases (Cochrane, PubMed, MEDLINE, EMBASE, SinoMed, and CNKI) were searched without language restrictions. Twelve randomized controlled trials involving a total of 1,030 patients were identified. The results indicate that unilateral PKP had a better degree of pain relief (visual analog scale) than bilateral PKP ( p = 0.04; 95%CI = −0.36 to −0.00) with short‐term follow‐up (within 4 weeks) after operation. The radiological outcome assessment with short‐term follow‐up after operation indicates bilateral PKP had a better degree of anterior vertebral height restoration ( p = 0.03; 95%CI = −2.58 to −0.14). Operation time and cement dosage were less for unilateral PKP ( p < 0.05). There were no differences in complications such as cement leakage and adjacent vertebral fractures between two approaches ( p = 0.06 and p = 0.97, respectively). Life quality assessment (SF‐36) indicates unilateral PKP had a better result of bodily pain relief ( p < 0.05; 95%CI = 3.93 to 7.48) and general health benefit ( p < 0.05; 95%CI = 0.02 to 2.93) with short‐term follow‐up after operation. We suggest that a unilateral PKP is advantageous. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1713–1723, 2015.