Premium
Correlation between mechanical stress by finite element analysis and 18 F‐fluoride PET uptake in hip osteoarthritis patients
Author(s) -
Hirata Yasuhide,
Inaba Yutaka,
Kobayashi Naomi,
Ike Hiroyuki,
Yukizawa Yohei,
Fujimaki Hiroshi,
Tezuka Taro,
Tateishi Ukihide,
Inoue Tomio,
Saito Tomoyuki
Publication year - 2015
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.22717
Subject(s) - osteoarthritis , fluoride , finite element method , stress (linguistics) , correlation , nuclear medicine , medicine , materials science , physics , chemistry , pathology , mathematics , inorganic chemistry , alternative medicine , linguistics , philosophy , geometry , thermodynamics
Abstract 18 F‐fluoride positron emission tomography ( 18 F‐fluoride PET) is a functional imaging modality used primarily to detect increased bone metabolism. Increased 18 F‐fluoride PET uptake suggests an association between increased bone metabolism and load stress at the subchondral level. This study therefore examined the relationship between equivalent stress distribution calculated by finite element analysis and 18 F‐fluoride PET uptake in patients with hip osteoarthritis. The study examined 34 hips of 17 patients who presented to our clinic with hip pain, and were diagnosed with osteoarthritis or pre‐osteoarthritis. The hips with trauma, infection, or bone metastasis of cancer were excluded. Three‐dimensional models of each hip were created from computed tomography data to calculate the maximum equivalent stress by finite element analysis, which was compared with the maximum standardized uptake value (SUV max ) examined by 18 F‐fluoride PET. The SUV max and equivalent stress were correlated (Spearman's rank correlation coefficient ρ = 0.752), and higher equivalent stress values were noted in higher SUV max patients. The correlation between SUV max and maximum equivalent stress in osteoarthritic hips suggests the possibility that 18 F‐fluoride PET detect increased bone metabolism at sites of stress concentration. This study demonstrates the correlation between mechanical stress and bone remodeling acceleration in hip osteoarthritis. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:78–83, 2015.