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Human polyethylene granuloma tissues inhibit bone healing in a novel xenograft animal model
Author(s) -
Esposito Christina I.,
Oliver Rema A.,
Campbell Patricia A.,
Yu Yan,
Walter William L.,
Walter William K.,
Walsh William R.
Publication year - 2014
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.22588
Subject(s) - osteolysis , periprosthetic , medicine , granuloma , arthroplasty , human bone , joint replacement , in vivo , polyethylene , pathology , surgery , dentistry , in vitro , chemistry , biology , biochemistry , microbiology and biotechnology , organic chemistry
During revision of a conventional polyethylene joint replacement, surgeons usually remove the source of osteolysis (polyethylene) but cannot always remove all of the polyethylene granuloma tissues. We developed a human/rat xenograft model to investigate the effects of polyethylene granuloma tissues on bone healing. Human osteoarthritic and periprosthetic tissues collected during primary and revision hip arthroplasty surgeries were transplanted into the distal femora of athymic nude rats. After 3 weeks in vivo, there was a significant difference in the bone volume fraction ( V f ) between empty, primary, and revision defects ( p = 0.02), with a lower V f in defects with revision granuloma tissues compared to defects with primary osteoarthritic tissues. Polyethylene granuloma tissues in trabecular bone defects inhibited bone healing. Therefore, debridement around a metal‐on‐polyethylene hip replacement may shorten the time it takes to achieve secondary stability around a revision hip replacement. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:735–743, 2014.