Premium
microRNAs and cartilage
Author(s) -
Gibson Gary,
Asahara Hiroshi
Publication year - 2013
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.22397
Subject(s) - microrna , cartilage , biology , regulation of gene expression , gene expression , function (biology) , gene , computational biology , homeostasis , bioinformatics , microbiology and biotechnology , genetics , anatomy
microRNAs are small non‐coding RNAs that in the last decade have emerged as overarching regulators of gene expression. Their abundance, ability to repress a large number of target genes and overlapping target specificity indicate a complex network of interactions that is still being defined. A number of studies focused on the role of microRNAs in cartilage have identified a small number, including miR‐140 and ‐675 as playing important roles in regulation of cartilage homeostasis and together with the broader description of the activity of microRNAs in other tissues are beginning to define the function of microRNAs in cartilage development and homeostasis. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1333–1344, 2013.