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Glucuronoxylomannan facilitates generation of chondrocytes from bone marrow‐derived mononuclear cells
Author(s) -
Zhou Aiguo,
An Hong,
Jiang Dianming,
Zhang Jian
Publication year - 2012
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.22105
Subject(s) - peripheral blood mononuclear cell , bone marrow , microbiology and biotechnology , biology , chemistry , immunology , in vitro , biochemistry
Chondrocyte generation is an important process in cartilage and bone repair. Factors facilitating the induction of chondrocyte need to be further investigated. The present study aims to investigate the role of glucuronoxylomannan (Gxm) in the generation of chondrocytes. Human bone marrow cells were prepared using to generate the chondrocytes in the presence of Gxm. The results showed that Gxm has the capacity to facilitate the generation of chondrocytes in which transforming growth factor (TGF)‐β played a critical role. The Bmmc‐derived CD14+ cells were the major source of TGF‐β in the culture. The present study indicates that Gxm is a potential drug candidate to be used in the generation of chondrocyte. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:1690–1694, 2012