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Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament
Author(s) -
Fleming Braden C.,
Magarian Elise M.,
Harrison Sophia L.,
Paller David J.,
Murray Martha M.
Publication year - 2010
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.21071
Subject(s) - scaffold , fibrous joint , anterior cruciate ligament , medicine , anterior cruciate ligament reconstruction , knee joint , wound healing , surgery , ligament , platelet rich plasma , anatomy , biomedical engineering , platelet
Primary suture anterior cruciate ligament (ACL) repair was abandoned in favor of reconstruction due to a high rate of clinical failures. However, the insertion of a collagen scaffold loaded with platelets into the wound at the time of suture repair (“enhanced primary repair”) has been shown to improve functional healing in animal models. Our objectives were to determine if using a collagen scaffold alone (without platelets) would be sufficient to increase the structural properties of the repaired ACL and decrease postoperative knee laxity compared to suture repair without the scaffold. Eight Yucatan minipigs underwent bilateral ACL transection and suture repair. In one knee, the repair was augmented with a collagen scaffold (SCAFFOLD group) while the other had suture alone (SUTURE group). After 13 weeks of healing, knee joint laxity and the structural properties of the ACL were measured. The addition of the collagen scaffold to suture repair of a transected ACL did not significantly improve the mean anteroposterior knee laxity [SCAFFOLD vs. SUTURE: 6.1 ± 1.4 vs. 4.4 ± 2.0 mm ( p = 0.07), 8.1 ± 2.0 vs. 7.6 ± 2.0 mm ( p = 0.66), and 6.2 ± 1.2 vs. 6.1 ± 1.8 mm ( p = 0.85) at 30°, 60°, and 90° flexion, respectively]. Likewise, there were no significant differences in the structural properties [SCAFFOLD vs. SUTURE: 367 ± 185.9 vs. 322 ± 122.0N ( p = 0.66) and 90.7 ± 29.5 vs. 85.0 ± 30.3N/mm ( p = 0.74) for the yield load and linear stiffness, respectively]. The use of a collagen scaffold alone to enhance suture repair of the ACL was ineffective in this animal model. Future work will be directed at stimulating biological activity in the scaffold. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:703–709, 2010