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Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model
Author(s) -
Cadet Edwin R.,
Vorys George C.,
Rahman Ra'Kerry,
Park SangHyun,
Gardner Thomas R.,
Lee Francis Y.,
Levine William N.,
Bigliani Louis U.,
Ahmad Christopher S.
Publication year - 2010
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.20972
Subject(s) - rotator cuff , medicine , tendon , humerus , rotator cuff injury , footprint , bone density , orthodontics , urology , osteoporosis , surgery , paleontology , biology
The purpose of this study was to investigate whether supraspinatus tendon failure stress at the footprint can increase by improving the bone density at the rotator cuff footprint in a rat model. Bilateral ovariectomies were performed in twenty‐four 4‐month‐old Sprague‐Dawley rats. Half received bisphosphonate (zoledronic acid) and the other half received no treatment (OVX + ZOM and OVX, respectively). Twelve additional rats did not undergo ovariectomy or receive bisphosphonate treatment (CON). All rats were sacrificed at 7 months of age. Quantitative micro‐computed tomography was used to assess bone density in the proximal humerus. A series of stress–relaxation tests were performed to assess stiffness and failure stress of the supraspinatus tendon. Bone density in OVX + ZOM was significantly higher at the rotator cuff footprint when compared to CON and OVX rats ( p < 0.0001). The supraspinatus tendons in the OVX group were significantly stiffer when compared to the CON and OVX + ZOM groups ( p < 0.05). The failure stress of the OVX + ZOM group was significantly greater than the CON and OVX groups (22.89 ± 4.43 MPa vs. 18.36 ± 3.16 and 17.70 ± 4.92, respectively). In conclusion, improving the bone density at the rotator cuff footprint enhances failure stress of the suprapinatus tendon. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:308–314, 2010