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The impact of colony‐stimulating factor‐1 on fracture healing: An experimental study
Author(s) -
Sarahrudi Kambiz,
Mousavi Mehdi,
Grossschmidt Karl,
Sela Nezir,
König Franz,
Vécsei Vilmos,
Aharinejad Seyedhossein
Publication year - 2009
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.20680
Subject(s) - fracture (geology) , bone healing , medicine , materials science , composite material , surgery
Abstract The role of colony stimulating factor‐1 (CSF‐1) in the regulation of osteoclasts and bone remodeling suggests that CSF‐1 may also be involved in regulation of bone healing. The ability of CSF‐1 to promote healing of bone defects was tested in a rabbit model. Twenty‐four New Zeeland rabbits were included in the study. Animals were assigned to two groups: the control group ( n = 12) was treated by plate fixation. The animals in the second group ( n = 12) were also stabilized by conventional plating and received additionally CSF‐1 for 2 weeks systemically. Histologic, histomorphometric, and radiologic examinations were performed to evaluate the healing process at 4, 8, and 12 weeks following surgery. Animals that were treated by CSF‐1 produced a significantly higher amount of mineralized bone over the first 8 weeks after fracture compared to the control animals. Furthermore, a higher number of osteoclasts was found in CSF‐1‐treated animals within the first 8 weeks, compared to the controls. The present data emphasize for the first time the importance of CSF‐1 in the bone healing. The use of CSF‐1 in addition to conventional fixation might be a novel approach for the treatment of bone defects. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:36–41, 2009