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Role of fibroblasts and fibroblast‐derived growth factors in periprosthetic angiogenesis
Author(s) -
TunyogiCsapo Miklos,
Koreny Tamas,
Vermes Csaba,
Galante Jorge O.,
Jacobs Joshua J.,
Glant Tibor T.
Publication year - 2007
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.20449
Subject(s) - rankl , osteoprotegerin , periprosthetic , cancer research , angiogenesis , monocyte , vascular endothelial growth factor , growth factor , fibroblast growth factor , macrophage , osteoclast , medicine , chemistry , immunology , pathology , receptor , activator (genetics) , in vitro , surgery , biochemistry , arthroplasty , vegf receptors
The periprosthetic granulomatous soft tissue [designated iterfacial membrane (IFM) in this study] exhibits heterogeneous histopathological features, in which highly vascularized areas with dense cellularity alternate with fibrotic and pseudocapsule‐like tissue structures. Although macrophage/monocyte activation is a prominent event in the periprosthetic environment, fibroblasts also phagocytose particulate wear debris both in vivo and in vitro. Particulate wear debris and/or cytokines/growth factors alone or in combination (e.g., in conditioned media of explant cultures of IFMs) stimulated normal synovial and IFM fibroblasts to express inflammatory mediators and growth factors such as interleukin (IL)‐1β, IL‐6, IL‐8, three isoforms of vascular endothelial growth factor (VEGF), monocyte/macrophage chemoattractant protein‐1 (MCP‐1), macrophage‐colony‐stimulating factor (M‐CSF), cycloxygenases (Cox‐1 and Cox‐2), acid‐ and basic‐fibroblast growth factors (FGF‐1 and FGF‐2), leukemia inhibitory factor‐1 (LIF‐1), transforming growth factor β‐1 (TGF‐β1), receptor activator of nuclear factor‐kappa B ligand (RANKL), and osteoprotegerin (OPG). Thus, the fibroblast is capable of expressing a wide array of angiogenic and osteoclastogenic factors which are involved in the detrimental processes of the periprosthetic osteolysis. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:1378–1388, 2007