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Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells
Author(s) -
Luu Hue H.,
Song WenXin,
Luo Xiaoji,
Manning David,
Luo Jinyong,
Deng ZhongLiang,
Sharff Katie A.,
Montag Anthony G.,
Haydon Rex C.,
He TongChuan
Publication year - 2007
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.20359
Subject(s) - bone morphogenetic protein 2 , mesenchymal stem cell , bone morphogenetic protein 7 , bone morphogenetic protein , microbiology and biotechnology , bone morphogenetic protein 6 , regeneration (biology) , biology , medicine , in vitro , genetics , gene
Efficacious bone regeneration could revolutionize the clinical management of many bone and musculoskeletal disorders. Bone morphogenetic proteins (BMPs) can regulate the differentiation of mesenchymal stem cells into cartilage, bone, tendon/ligament, and fat lineages. Early data documented the osteogenic potential of rhBMP2 and rhBMP7/OP‐1. However, prior to this work that summarized several of our recent studies, no comprehensive analysis had been undertaken to characterize relative osteogenic activity of all BMPs. Using recombinant adenoviruses expressing 14 BMPs, we have demonstrated that, besides BMP2 and BMP7, BMP6 and BMP9 exhibit the highest osteogenic activity both in vitro and in vivo. We further demonstrated that several BMPs may exert synergistic effect on osteogenic differentiation, and that osteogenic BMPs produce a distinct set of molecular fingerprints during osteogenic differentiation. The reported work should expand our current understanding of BMP functions during osteogenic differentiation. It is conceivable that osteogenic BMPs (i.e., BMP2, 4, 6, 7, and 9) may be used to formulate synergistic pairs among themselves and/or with other less osteogenic BMPs for efficacious bone regeneration in clinical settings. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:665–677, 2007