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Lumbar body fusion with a bioresorbable cage in a goat model is delayed by the use of a carboxymethylcellulose‐stabilized collagenous rhOP‐1 device
Author(s) -
Mullender Margriet G.,
Krijnen Matthijs R.,
Helder Marco N.,
Smit Theo H.,
Everts Vincent,
Wuisman Paul I.J.M.
Publication year - 2007
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.20285
Subject(s) - cage , medicine , lumbar , spinal fusion , surgery , soft tissue , mathematics , combinatorics
The purpose of this study was to evaluate the efficacy of recombinant human osteogenic protein‐1 (rhOP‐1) with a carboxymethylcellulose‐stabilized collagenous carrier as a bone graft substitute for instrumented lumbar spinal fusion in an established goat model. Twenty goats received a resorbable poly‐ L ‐lactic acid (PLLA) interbody cage packed with either rhOP‐1 and its carrier or autologous bone graft. The carrier material was bovine collagen type‐1 stabilized with carboxymethylcellulose. The fusion segments were retrieved at 3 or 6 months postimplantation and evaluated by radiographic and histologic analyses. The rhOP‐1 graft substitute, used in combination with the resorbable PLLA cage, showed inferior results as compared to autologous bone graft in the goat lumbar fusion model. Whereas four out of five segments from the autograft group were fused after 6 months, none of the four segments receiving the rhOP‐1 graft substitute were fused at this time point. Bone ingrowth into the cage was delayed or absent in the experimental group, whereas all autograft specimens showed advanced bone ingrowth (3 months) or fusion (6 months). We suggest that the fusion process was inhibited, because cells were unable to penetrate the rhOP‐1 graft material. This led to delayed bone formation and in some cases inadequate tissue formation. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:132–141, 2007