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Local alendronate increases fixation of implants inserted with bone compaction: 12‐week canine study
Author(s) -
Jakobsen Thomas,
Kold Søren,
Bechtold Joan. E.,
Elmengaard Brian,
Søballe Kjeld
Publication year - 2007
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.20276
Subject(s) - osseointegration , implant , bisphosphonate , medicine , dentistry , fixation (population genetics) , intramedullary rod , tibia , osteoporosis , surgery , environmental health , population
Abstract Bone compaction has been shown to increase initial implant fixation. Furthermore, bone compaction creates a peri‐implant zone of autograft that exerts osteoconductive properties. We have previously shown that locally applied bisphosphonate (alendronate) at 4‐week observation can preserve the autograft generated by bone compaction. We now investigate whether the increased amount of autograft, seen at 4 weeks, can increase implant osseointegration and biomechanical fixation. Porous‐coated titanium implants were bilaterally inserted with bone compaction into the proximal part of tibia of 10 dogs. On the right side, local bisphosphonate was injected into the bone cavity prior to bone compaction immediately prior to implant insertion . On the left side, saline was used as control. Observation period was 12 weeks. Locally applied bisphosphonate significantly increased biomechanical implant fixation (approximately twofold), bone‐to‐implant contact (1.2‐fold), and peri‐implant bone volume fraction (2.3‐fold). This study indicates that local alendronate treatment can increase early implant osseointegration and biomechanical fixation of implants inserted by use of bone compaction. Long term effects remain unknown. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:432–441, 2007