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Evaluation of a novel biomaterial for intrasubstance muscle laceration repair
Author(s) -
Crow Bradley D.,
Haltom J. Douglas,
Carson William L.,
Greene Walter B.,
Cook James L.
Publication year - 2007
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.20232
Subject(s) - medicine , prolene , surgery , fibrous joint , muscle belly , regeneration (biology) , anatomy , tendon , biology , microbiology and biotechnology
The authors compare the effects of small intestinal submucosa (SIS) treatment to suture repair with respect to histologic and functional outcomes for complete muscle lacerations in a rabbit model. The authors hypothesized that SIS treatment of full‐thickness muscle belly lacerations would significantly improve muscle function, strength, and regeneration compared to the current standard‐of‐care treatment. Muscle belly lacerations were created in the extensor digitorum longus (EDL) of both hind limbs of each rabbit. After randomization, lacerations were left unrepaired ( n = 48) or repaired using a 4‐0 Prolene modified Kessler stitch ( n = 48). A flap of SIS graft was sutured into half ( n = 24 each) of the repaired and unrepaired muscles forming four study groups. Suture repair with SIS augmentation of complete muscle lacerations resulted in healed tissue that most closely resembled normal muscle in terms of morphology and function when compared to current standard‐of‐care treatments. Active force production in this group reached 79% of uninjured controls 12 weeks after surgery. SIS may have important clinical advantages over suture repair alone and warrants further clinical study. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 2007