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Collagen network primarily controls Poisson's ratio of bovine articular cartilage in compression
Author(s) -
Kiviranta Panu,
Rieppo Jarno,
Korhonen Rami K.,
Julkunen Petro,
Töyräs Juha,
Jurvelin Jukka S.
Publication year - 2006
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.20107
Subject(s) - poisson's ratio , cartilage , modulus , articular cartilage , aggregate modulus , poisson distribution , anatomy , biomedical engineering , materials science , chemistry , osteoarthritis , pathology , dynamic modulus , medicine , composite material , dynamic mechanical analysis , mathematics , polymer , statistics , alternative medicine
The equilibrium Young's modulus of articular cartilage is known to be primarily determined by proteoglycans (PGs). However, the relation between the Poisson's ratio and the composition and structure of articular cartilage is more unclear. In this study, we determined Young's modulus and Poisson's ratio of bovine articular cartilage in unconfined compression. Subsequently, the same samples, taken from bovine knee (femoral, patellar and tibial cartilage) and shoulder (humeral cartilage) joints, were processed for quantitative microscopic analysis of PGs, collagen content, and collagen architecture. The Young's modulus, Poisson's ratio, PG content (estimated with optical density measurements), collagen content, and birefringence showed significant topographical variation ( p < 0.05) among the test sites. Experimentally the Young's modulus was strongly determined by the tissue PG content ( r = 0.86, p < 0.05). Poisson's ratio revealed a significant negative linear correlation ( r = −0.59, p < 0.05) with the collagen content, as assessed by the Fourier transform infrared imaging. Finite element analyses, conducted using a fibril reinforced biphasic model, indicated that the mechanical properties of the collagen network strongly affected the Poisson's ratio. We conclude that Poisson's ratio of articular cartilage is primarily controlled by the content and organization of the collagen network. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res